The programing of the FMC is different depending on the FMC installed. FMC is only used for a GPS approach or missed approach procedures. Normally, the aircraft is on a radar vector(heading) when within approximately 30-40 miles of the airport. You would load the GPS approach and use heading mode to intercept the GPS approach centerline and NAV mode to maintain. Normally there is no vertical guidance during a GPS approach, there are exceptions based on certain approved equipment.
ILS and other approaches:
Some FMC will allow the approach to be loaded for situational awareness(SA) purposes and for use in flying the missed approach procedure. VOR/LOC equipment is providing the guidance during the approach, the FMC only draws a picture of the approach on the FMC display to help the crews SA.
Flight Simulator only:
Since you may not use ATC, you can set up the transition to the approach on your own. Look for a intersection, any(let's call it the initial point{IP}) that is approximately 10-20 miles from the airport, on the centerline of the desired approach and depicted on the instrument approach chart(you need a chart to fly a correct approach). Sometimes such a fix may show in the FMC if it allows approach selection. Make this IP a waypoint before the airport on your route of flight. As you reach the IP, go to VOR/LOC NAV and intercept the ILS.