I bought MSTS yesterday and I installed and played it. I closed it to eat dinner and came back to play and I got in the game and loaded up a mission only to find out the keyboard no longer works! The only way to get out of the game is to Ctrl+Alt+Delete out of it, when task manager comes up I saw the CPU usage read 100%.
My system is....
Pentium 4 2.2GHz
256MB ATI Radeon 9250.
1GB RAM
I have MSTS installed on my 250GB external HD. I know it's not the HD because I have FSX, BF1942, SWBF2, Lego Star Wars 2, LOMAC, JetFighter 2015, MX vs. ATV, SC4, and Civilization IV on the HD and they work flawlessly.
1 Answers
Try defragging all drives and rebooting.

Still stuck on this question?
Ask Fly Away, our AI flight sim & aviation assistant, for an instant answer to this exact question — or ask the community below.
Train Sims — recently answered
Train SimsWhere can I download Shinkansen train add-ons?Find Shinkansen train add-ons for MSTS and Train Simulator Classic, with compatibility checks…Read answer →Train SimsHow do I use a button box with a train simulator?Set up a train simulator button box on PC, choose direct USB or keyboard mapping, assign…Read answer →Train SimsCan you play train simulator games online for free?See which free online train simulator games run in a browser, when a PC download is better…Read answer →Train SimsCan you use a train simulator in VR?Use a train simulator in VR: see which games have native support, the hardware required, and…Read answer →
Trainee
Chief Captain